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  • Article dans une revue

Acidic Osteoid Templates the Plywood Structure of Bone Tissue

Marc Robin, Chakib Djediat, Arnaud Bardouil, Niki Baccile, Camille Chareyron, Ivo Zizak, Peter Fratzl, Mohamed Selmane, Bernard Haye, Isabelle Genois, Jean‐marc Krafft, Guylène Costentin, Thierry Azaïs, Franck Artzner, Marie‐madeleine Giraud-Guille, Paul Zaslansky, Nadine Nassif

Bone is created by osteoblasts that secrete osteoid after which an ordered texture emerges, followed by mineralization. Plywood geometries are a hallmark of many trabecular and cortical bones, yet the origin of this texturing in vivo has never been shown. Nevertheless, extensive in vitro work…

Advanced Science, 2023, pp.2304454. ⟨10.1002/advs.202304454⟩. ⟨hal-04384750⟩

  • Article dans une revue

Deciphering pathological remodelling of the human cartilage extracellular matrix in osteoarthritis at the supramolecular level

Ilhem Lilia Jaabar, Pauline Cornette, Antoine Miche, Kristell Wanherdrick, Vincent Dupres, François-Paul Ehkirch, Adeline Cambon Binder, Francis Berenbaum, Xavier Houard, Jessem Landoulsi

Osteoarthritis induces a combination of chemical, structural and nanomechanical changes to collagen fibrils and aggrecan aggregates, the main building blocks of cartilage ECM, that may be mimicked by specific enzymatic reactions.

Nanoscale, 2022, 14 (24), pp.8691-8708. ⟨10.1039/d2nr00474g⟩. ⟨hal-03986333⟩

  • Communication dans un congrès

Photochemistry of organic molecules in the Solar System: experimental studies outside the International Space Station. The cases of glycine, and nucleobases

Hervé Cottin, Giovanni Strazzulla, M. Dobrijevic, Frances Westall, Gaelle Coussot, A. Le Postollec, Nicolas Fray, Didier Chaput, Richard C. Quinn, . Andrew Mattioda, Giuseppe Baratta, Mario Accolla, Thomas Georgelin, Fabien Stalport, Laura Rouquette, Cyril Szopa, Kafila Saiagh, Jodie Bellila, Katia Grira, Andreas Elsaesser, Nathalie Carrasco, Avinash-Vicholous Dass, M. E. Palumbo

Solar UV radiation is a major source of energy for initiating chemical evolution towards complex organic structures, but it can also photo-dissociate even the most complex molecules. Thus, solar UV can erase the organic traces of past life at the surface of planets, such as Mars, destroy organic…

42nd COSPAR Scientific Assembly, Jul 2018, Pasadena, Californie, United States. ⟨hal-01901917⟩